Resume Gene Cutler, PhD
Career History
RAPT Therapeutics (formerly FLX Bio)
2018 to 2021 | Senior Director
Computational Biology | Quantitative Biology
Continue to apply Big Data to accelerate drug discovery, including Clinical Trial Biomarker Strategy and Analysis
FLX Bio
2015 to 2018 | Director
Computational Biology | Quantitative Biology
Created FLX Bio’s Computational Biology Group, applying Big Data to all stages of drug discovery from Target ID to Patient Selection Strategies and Clinical Biomarker Planning
Amgen
2011 to 2015 | Scientific Director
Genome Analysis Unit | Discovery Research
Co-lead of the Omics/Computational Biology Group for the Amgen Discovery organization
Amgen
2002 to 2011 | Principal Scientist
Computational Biology | Therapeutic Discovery
Focused on Discovery in Metabolic Disease and Oncology
Tularik
2000 to 2002 | Scientist
Computational Biology | Biology
Tularik
1998 to 2000 | Postdoctoral Fellow
Metabolic Disease | Biology
University of California, Berkeley
1998 | Postdoctoral Fellow
Lab of Dr. Robert Tjian | Molecular & Cell Biology
Education
University of California, Berkeley
1992-1997 | PhD, Molecular and Cell Biology
Lab of Dr. Robert Tjian
Cornell University
1988-1992 | BA, College of Arts and Sciences
Biology Major
Journal Publications
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4
L Marshall, S Marubayashi, A Jorapur, A Jacobson, M Zibinsky, O Robles, D Hu, J Jackson, D Pookot, J Sanchez, M Brovarney, A Wadsworth, D Chian, D Wustrow, P Kassner, Gene Cutler, B Wong, D Brockstedt, O Talay
Journal for Immunotherapy of Cancer | 11/2020
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity in Vitro and in Vivo
Y Ohol, M Sun, Gene Cutler, P Leger, D Hu, B Biannic, P Rana, C Cho, S Jacobson, S Wong, J Sanchez, N Shah, D Pookot, B Abraham, K Young, S Suthram, L Marshall, D Bradford, N Kozon, X Han, A Okano, J Maung, C Colas, J Schwarz, D Wustrow, D Brockstedt, P Kassner
Molecular Cancer Therapeutics | 10/2020
Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors
O Robles, J Jackson, L Marshall, O Talay, D Chian, G Cutler, R Diokno, D Hu, S Jacobson, E Karbarz, P Kassner, J Ketcham, J McKinnell, C Meleza, M Reilly, E Riegler, H Shunatona, A Wadsworth, A Younai, D Brockstedt, D Wustrow, M Zibinsky
Journal of Medicinal Chemistry | 7/2020
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4
L Marshall, S Marubayashi, A Jorapur, A Jacobson, M Zibinsky, O Robles, Dennis X Hu, J Jackson, D Pookot, J Sanchez, M Brovarney, A Wadsworth, D Chian, D Wustrow, P Kassner, G Cutler, B Wong, D Brockstedt, O Talay
Journal for Immunotherapy of Cancer | 11/2020
Targeting The Stress Response Kinase GCN2 To Restore Immunity In The Tumor Microenvironment
L Marshall, B Ravishankar, L Adusumilli, M Zibinsky, D Pookot, E Huang, O Talay, S Suthram, J Jackson, G Shibuya, P Leger, P Tivitmahaisoon, A Okal, D Bradford, C Colas, G Cutler, J Schwartz, Wustrow, P Kassner, D Brockstedt
Journal for Immunotherapy of Cancer | 11/2019
Discovery of potent and selective inhibitors of USP7 with anti-tumor activity in vitro and in vivo
Y Ohol, M Sun, G Cutler, P Leger, D Hu, B Biannic, P Rana, C Cho, S Jacobson, S Wong, J Sanchez, X
Han, K Young, A Okano, N Shah, B Abraham, D Pookot, J Maung, D Bradford, N Kozon, S Suthram, L
Adusumilli, D Kaveri, O Talay, C Colas, A Kim, J Schwarz
Cancer Research | 7/2019
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor
Microenvironment
J Jackson, J Ketcham, A Younai, B Abraham, B Biannic, H Beck, M Bui, D Chian, G Cutler, R Diokno, D
Hu, S Jacobson, E Karbarz, P Kassner, L Marshall, J McKinnell, C Meleza, A Okal, D Pookot, M Reilly, O
Robles, H Shunatona, O Talay, J Walker, A Wadsworth, D Wustrow, M Zibinsky
Journal of Medicinal Chemistry | 6/2019
FLX925 Is a Rationally Designed FLT3, CDK4/6 Inhibitor with a Desirable Resistance Profile
S Marubayashi, A Park, R Noubade, H Phan, G Cutler, P Kassner, JS Fridman
Blood | 12/2016
A Machine-Learning Analysis Suggests That FLX925, a FLT3/CDK4/6 Kinase Inhibitor, Is Potent
Against FLT3-Wild Type Tumors Via Its CDK4/6 Activity
G Cutler, JS Fridman
Blood | 12/2016
Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using
hydrodynamic intravascular injection
H Baribault, JZ Majeti, H Ge, J Wang, Y Xiong, J Gardner, L Yang, J Gupte, Y Gong, Z Pan, G Cutler, PD
Kassner, H Tu, B Shan, X Wu, and Y Li
Expert opinion on therapeutic targets | 11/2014
Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial
signaling pathways
R Blum, R Gupta, PE Burger, CS Ontiveros, SN Salm, X Xiong, A Kamb, H Wesche, L Marshall, G Cutler,
X Wang, J Zavadil, D Moscatelli, EL Wilson
PLoS One | 09/30/2010
Identification of transcriptional networks responding to pyrroloquinoline quinone dietary
supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK
pathways
E Tchaparian, L Marshal, G Cutler, K Bauerly, W Chowanadisai, M Satre, C Harris, RB Rucker
Biochemical Journal | 08/01/2010
Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights
into prostate cancer
R Blum, R Gupta, PE Burger, CS Ontiveros, SN Salm, X Xiong, A Kamb, H Wesche, L Marshall, G Cutler,
X Wang, J Zavadil, D Moscatelli, EL Wilson
PloS One | 05/09/2009
Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease
G Cutler, PD Kassner
Cytogenetics and Genome Research | 03/11/2009
Significant gene content variation characterizes the genomes of inbred mouse strains
G Cutler, LA Marshall, N Chin, H Baribault, PD Kassner
Genome Research | 01/12/2007
Impact of diet on hepatic gene expression in response to selected drugs and nutrients
E Tchaparian, K Bauerly, C Harris, M Satre, W Chowanadisai, G Cutler, L Marshall, A Mitchell, R Rucker
FASEB Journal | 03/2007
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
S Herter, D Piper, W Aaron, T Gabriele, G Cutler, P Cao, A Bhatt, Y Choe, C Craik, N Walker, D Meininger, T Hoey, R Austin
Biochemical Journal | 08/15/2005
Multiclass cancer classification and biomarker discovery using GA-based algorithms
JJ Liu, G Cutler, W Li, Z Pan, S Peng, T Hoey, L Chen, XB Ling
Bioinformatics | 06/01/2005
Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach
J Gupte, G Cutler, JL Chen, H Tian
Proceedings of the National Academy of Sciences | 02/10/2004
A comparative analysis of HGSC and Celera human genome assemblies and gene sets
S Li, G Cutler, JJ Liu, T Hoey, L Chen, PG Schultz, J Liao, XB Ling
Bioinformatics | 09/01/2003
Comparative analysis of human genome assemblies reveals genome-level differences
S Li, J Liao, G Cutler, T Hoey, JB Hogenesch, MP Cooke, PG Schultz, XB Ling
Genomics | 08/31/2002
Identification and characterization of a melanin-concentrating hormone receptor
S An, G Cutler, JJ Zhao, SG Huang, H Tian, W Li, L Liang, M Rich, A Bakleh, J Du, JL Chen, K Dai Proceedings of the National Academy of Sciences | 06/19/2001
Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif
G Cutler, KM Perry, R Tjian
Molecular and cellular biology | 04/01/1998
Contacts in context: promoter specificity and macromolecular interactions in transcription
JA Goodrich, G Cutler, R Tjian
Cell | 03/22/1996
Other Media
INTERVIEW
Next Generation Sequencing Roundtable
November 14, 2011
BOOK CHAPTER
Genomic resources for cancer biologists
XB Ling, G Cutler, T Hoey
Select Patents
Ubiquitin-specific-processing protease 7 (usp7) modulators and uses thereof
B Biannic, X Han, D Hu, P Leger, J Maung, A Okano, J Schwarz, D Wustrow, K Young, Gene Cutler, Y Ohol-Gupta
US Patent 16578276 | 03/26/2020
Antibodies which bind to SCNN1A/TNFRSF1A fusion proteins and methods of use thereof
KC Quon, G Cutler, JJ Kordich
US Patent 8,735,548 | 05/27/2014
FUSION PROTEINS IN CANCER
KC Quon, G Cutler, JJ Kordich
US Patent 20130095111 | 04/18/2013
SCNN1A/TNFRSF1A FUSION PROTEINS IN CANCER
KC Quon, G Cutler, JJ Kordich
WO Patent 2012012141 | 01/27/2012
NOVEL RECEPTORS
JL Chen, G Cutler, K Dai, H Tian, J Zhao
US Patent 11/680,133 | 02/28/2007
NOVEL RECEPTORS
H Tian, J Zhao, JL Chen, G Cutler
US Patent 11/086,846 | 03/21/2005